December 31, 2010
– Comments (2)
Pretty good summary from Genetic and Engineering News.
Includes advances in sequencing, stem cells, and cancer vaccines.
Home Coverage Fool
From the article:" A look at last year’s stories reveals much to-do about the anti-aging potential of sirtuins, that beloved chemical in red wine."
Well then, I'll just continue to get my sirtuins the more enjoyable traditional way.
The chemical in red wine is resveratrol, which was in clinical development but has been shelved (pun intended). Resveratrol was found to activate sirtuins, which is a family of proteins involved in DNA processing (storage). Sirtris, bought by GSK, developed second generation compounds that activate these proteins, but the science been partially questioned. Some of the observed acitvation may have been an artifact of the model and not true activity (perhaps).
I'd note that protein activation (rather than inhibition), other than extracellular receptors, is not a traditional mode of drug development.