Use access key #2 to skip to page content.

portefeuille (99.67)

fund trades

Recs

5

February 22, 2011 – Comments (207)

I will post the trades I make and some performance statistics. I will add a list showing all trades or some "background information" related to the trades occasionally.

What this "fund" is about is described here and here.

trades in spreadsheet.

Most trades are shown in these posts.

March 06, 2010
March 10, 2010
March 13, 2010
March 30, 2010
April 02, 2010
April 08, 2010
April 17, 2010
April 26, 2010
May 22, 2010
June 17, 2010
July 21, 2010
August 03, 2010
August 11, 2010
August 26, 2010
September 04, 2010
September 18, 2010
October 06, 2010
October 16, 2010
October 24, 2010
October 28, 2010
November 03, 2010
November 12, 2010
November 24, 2010
December 11, 2010
December 17, 2010
December 24, 2010
December 27, 2010
December 31, 2010
January 12, 2011
February 01, 2011
February 10, 2011

207 Comments – Post Your Own

#1) On February 22, 2011 at 9:49 AM, portefeuille (99.67) wrote:

sold 400 TTHI 4.60 USD,
sold 1600 TAN 8.87 USD,
bought 300 SQNM 6.31 USD.

Report this comment
#2) On February 22, 2011 at 9:55 AM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 22, 2011): 43.86%,
rel. change of fund (March 8, 2010 - February 22, 2011) with a DSCO share price at the break-even price of the DSCO position (≈$2.767): 66.71%.

Report this comment
#3) On February 22, 2011 at 10:12 AM, portefeuille (99.67) wrote:

sold 400 EXEL 10.82 USD.

currently 850 EXEL shares in the fund with break-even of around -124.41 EUR.

Report this comment
#4) On February 22, 2011 at 10:12 AM, portefeuille (99.67) wrote:

-124.41 EUR

-124.41 USD

Report this comment
#5) On February 22, 2011 at 10:27 AM, portefeuille (99.67) wrote:

sell 1200 TSRX, limit 6.32 USD.

Report this comment
#6) On February 22, 2011 at 10:30 AM, portefeuille (99.67) wrote:

sell 3700 IDRA, limit 2.87 USD.

Report this comment
#7) On February 22, 2011 at 10:35 AM, portefeuille (99.67) wrote:

sold 100 XLF 17.00 USD.

Report this comment
#8) On February 22, 2011 at 11:07 AM, portefeuille (99.67) wrote:

sold 3700 IDRA 2.875 USD.

currently 17600 IDRA shares in the fund with break-even of around 2.58 EUR.

Report this comment
#9) On February 22, 2011 at 11:24 AM, portefeuille (99.67) wrote:

sell 1700 ANTH, limit 5.10 USD.

Report this comment
#10) On February 22, 2011 at 11:26 AM, portefeuille (99.67) wrote:

sold 1700 ANTH 5.28 USD.

currently 7100 ANTH shares in the fund with break-even of around -22.36 EUR.

 

sell 1100 ANTH, limit 5.55 USD.

Report this comment
#11) On February 22, 2011 at 11:38 AM, portefeuille (99.67) wrote:

2.58 EUR
-22.36 EUR

2.58 USD
-22.36 USD

 

bought 1200 ATPG 18.95 USD.

currently 17600 ATPG shares in the fund with break-even of around 5.5 USD.

Report this comment
#12) On February 22, 2011 at 11:52 AM, portefeuille (99.67) wrote:

sold 1200 TSRX 6.35 USD.

currently 2500 TSRX shares in the fund with break-even of around -1.51 USD.

Report this comment
#13) On February 22, 2011 at 11:58 AM, portefeuille (99.67) wrote:

sell 50 HAWK, limit 4.20 USD.

Report this comment
#14) On February 22, 2011 at 11:59 AM, portefeuille (99.67) wrote:

sold 50 HAWK 4.22 USD.

Report this comment
#15) On February 22, 2011 at 12:04 PM, portefeuille (99.67) wrote:

sell 1700 SKYD:GY, limit 3.27 EUR
buy 30000 DSCO, limit 2.08 USD
sell 150000 DSCO, limit 2.28 USD
sell 500 ALPHA:GA, limit 5.90 EUR

cancel these orders.

Report this comment
#16) On February 22, 2011 at 12:29 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 22, 2011): 40.5%,
rel. change of fund (March 8, 2010 - February 22, 2011) with a DSCO share price at the break-even price of the DSCO position (≈$2.767): 64.85%.

Report this comment
#17) On February 22, 2011 at 1:02 PM, portefeuille (99.67) wrote:

ATP Oil & Gas at EnerCom Incorporated The Oil & Services Conference (TOSC) Feb.22.11 3:10 p.m. PT

EnerCom Incorporated The Oil & Services Conference (TOSC) (pdf)

Report this comment
#18) On February 22, 2011 at 1:28 PM, portefeuille (99.67) wrote:

sold 1100 ANTH 5.57 USD.

Report this comment
#19) On February 22, 2011 at 1:38 PM, portefeuille (99.67) wrote:

buy 400 IBB, limit 94 USD.

Report this comment
#20) On February 22, 2011 at 1:41 PM, portefeuille (99.67) wrote:

bought 400 IBB 93.72 USD.

currently 695 IBB shares in the fund with break-even of around 25.7 USD.

Report this comment
#21) On February 22, 2011 at 2:04 PM, portefeuille (99.67) wrote:

sell 1900 VICL, limit 1.97 USD.

Report this comment
#22) On February 22, 2011 at 2:05 PM, portefeuille (99.67) wrote:

sold 1900 VICL 1.98 USD.

currently 7600 VICL shares in the fund with break-even of around 2.18 USD.

Report this comment
#23) On February 22, 2011 at 5:59 PM, portefeuille (99.67) wrote:

buy 150 HPQ, limit 42.30 USD.

Report this comment
#24) On February 22, 2011 at 6:00 PM, portefeuille (99.67) wrote:

bought 150 HPQ 42.14 USD.

Report this comment
#25) On February 22, 2011 at 6:05 PM, portefeuille (99.67) wrote:

buy 150 HPQ, limit 42.30 USD.

buy 150 HPQ, limit 42.30 USD in extended or regular trading.

 

currently 1120 HPQ shares in the fund with break-even of around 38.57 USD.

Report this comment
#26) On February 22, 2011 at 7:21 PM, BlackSwanCapital (63.77) wrote:

Hey porte,

I was wondering how many shares of: SVNT, EXAS, MNTA, and PBTH are in your fund?

Also, how do you feel about those companies at present?  

Report this comment
#27) On February 22, 2011 at 8:31 PM, TigerPack1 (81.28) wrote:

I am still holding ATPG from $10 a share average cost.

What is the story on PDLI from your perspective?  I put that one on my watch list after reading a few articles.

-TP

Report this comment
#28) On February 22, 2011 at 8:41 PM, portefeuille (99.67) wrote:

#26 There are currently 29300/13810/16750/23760 EXAS/MNTA/PBTH/SVNT shares in the fund with break-even of around 5.46/15.10/4.19/8.89 USD. I still like all of those stocks.

#27 I think I don't have anything to say about PDLI currently. There are 850 PDLI shares in the fund with break-even of around 4.31 USD.

Report this comment
#29) On February 23, 2011 at 7:24 AM, portefeuille (99.67) wrote:

Phase 3 Study of VX-770 Showed Profound and Sustained Improvements in Lung Function (FEV1) and Other Measures of Disease Among People With a Specific Type of Cystic Fibrosis

Vertex: Stellar Data for Cystic Fibrosis Drug

 

currently 290 VRTX shares in the fund with break-even of around 34.36 USD.

Report this comment
#30) On February 23, 2011 at 7:27 AM, portefeuille (99.67) wrote:

sell 70 VRTX, limit 43.30 USD in extended or regular trading.

Report this comment
#31) On February 23, 2011 at 8:20 AM, portefeuille (99.67) wrote:

sold 70 VRTX 46.00 USD.

Report this comment
#32) On February 23, 2011 at 8:41 AM, portefeuille (99.67) wrote:

sell 150 HPQ, limit 44 USD in extended or regular trading.

Report this comment
#33) On February 23, 2011 at 8:43 AM, portefeuille (99.67) wrote:

sold 150 HPQ 44.00 USD.

currently 970 HPQ shares in the fund with break-even of around 37.74 USD.

Report this comment
#34) On February 23, 2011 at 8:57 AM, portefeuille (99.67) wrote:

sell 60 OCLR, limit 16.30 USD in extended or regular trading.

Report this comment
#35) On February 23, 2011 at 8:59 AM, portefeuille (99.67) wrote:

sold 60 OCLR 16.61 USD.

currently 90 OCLR shares in the fund with break-even of around -78.80 USD.

Report this comment
#36) On February 23, 2011 at 9:36 AM, portefeuille (99.67) wrote:

buy 200 HPQ, limit 43 USD.

Report this comment
#37) On February 23, 2011 at 9:38 AM, portefeuille (99.67) wrote:

bought 200 HPQ 42.95 USD.

sell 4500 ALNY, limit 12 USD.

Report this comment
#38) On February 23, 2011 at 9:40 AM, portefeuille (99.67) wrote:

sold 4500 ALNY 12.08 USD.

currently 41050 ALNY shares in the fund with break-even of around 10.28 USD.

Report this comment
#39) On February 23, 2011 at 9:46 AM, portefeuille (99.67) wrote:

buy 3000 EMC, limit 26.50 USD.

Report this comment
#40) On February 23, 2011 at 9:48 AM, portefeuille (99.67) wrote:

bought 3000 EMC 26.23 USD.

currently 17500 EMC shares in the fund with break-even of around 14.24 USD.

Report this comment
#41) On February 23, 2011 at 9:55 AM, portefeuille (99.67) wrote:

buy 2500 ATPG, limit 17.80 USD.

Report this comment
#42) On February 23, 2011 at 9:58 AM, portefeuille (99.67) wrote:

bought 2500 ATPG 17.75 USD.

currently 20100 ATPG shares in the fund with break-even of around 7.02 USD.

Report this comment
#43) On February 23, 2011 at 10:04 AM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 23, 2011) with/without DSCO: 38.68/65.3%.

Report this comment
#44) On February 23, 2011 at 10:12 AM, portefeuille (99.67) wrote:

buy to cover 400 VMW, limit 83 USD.

Report this comment
#45) On February 23, 2011 at 10:14 AM, portefeuille (99.67) wrote:

bought to cover 400 VMW 82.56 USD.

Report this comment
#46) On February 23, 2011 at 10:42 AM, portefeuille (99.67) wrote:

buy 630 STEC, limit 20.50 USD.

Report this comment
#47) On February 23, 2011 at 10:45 AM, portefeuille (99.67) wrote:

bought 630 STEC 20.29 USD.

currently 1080 STEC shares in the fund with break-even of around 10.31 USD.

Report this comment
#48) On February 23, 2011 at 10:58 AM, portefeuille (99.67) wrote:

sell 1800 EMC, limit 26.38 USD.

Report this comment
#49) On February 23, 2011 at 10:58 AM, portefeuille (99.67) wrote:

sold 1800 EMC, limit 26.405 USD.

Report this comment
#50) On February 23, 2011 at 11:51 AM, portefeuille (99.67) wrote:

sell 180 EXEL, limit 11.47 USD.

Report this comment
#51) On February 23, 2011 at 11:54 AM, portefeuille (99.67) wrote:

sold 180 EXEL 11.50 USD.

currently 670 EXEL shares in the fund with break-even of around -160.92 USD.

Report this comment
#52) On February 23, 2011 at 12:04 PM, portefeuille (99.67) wrote:

sell 200 HPQ, limit 43 USD.

Report this comment
#53) On February 23, 2011 at 12:05 PM, portefeuille (99.67) wrote:

sold 200 HPQ 43.40 USD.

Report this comment
#54) On February 23, 2011 at 12:27 PM, portefeuille (99.67) wrote:

buy 250 TTHI, limit 3.97 USD.

Report this comment
#55) On February 23, 2011 at 12:29 PM, portefeuille (99.67) wrote:

bought 250 TTHI 3.95 USD.

currently 1450 TTHI shares in the fund with break-even of around -1.73 USD.

Report this comment
#56) On February 23, 2011 at 1:09 PM, portefeuille (99.67) wrote:

buy 800 LGND, limit 10 USD.

Report this comment
#57) On February 23, 2011 at 1:09 PM, Nickalisk (53.38) wrote:

Hello Porty,

I noticed that a lot of fools seemed to "follow" you on the DSCO green thumb - and you apparently own some shares in your real $$ portfolio, so I figured I'd ask:

What do you see happening here?  Is your conviction that the FDA is basically saying: "Yea, we'll greenlight this if you can fix batch irregularities?"  Is there some part of the story that I'm missing - and have you been quietly accumulating shares as it creeps lower recently?  I'm just trying to figure out your thought process before this rockets off and in retrospect seems like a no brainer.  Is this your largest position irl?

Report this comment
#58) On February 23, 2011 at 1:39 PM, portefeuille (99.67) wrote:

bought 800 LGND 9.95 USD.

currently 7050 LGND shares in the fund with break-even of around 8.66 USD.

 

#57 No, it is my second largest position behind EMC shares and EMC call options/warrants. I don't think there has been any "significant news" in the last few days. I don't know anything about DSCO that cannot be found quite easily.

Report this comment
#59) On February 23, 2011 at 2:53 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 23, 2011) with/without DSCO: 34.2/61.94%.

Report this comment
#60) On February 23, 2011 at 3:00 PM, portefeuille (99.67) wrote:

trades in spreadsheet.

Report this comment
#61) On February 23, 2011 at 3:27 PM, portefeuille (99.67) wrote:

buy 1300 CHTP, limit 4.15 USD.

Report this comment
#62) On February 23, 2011 at 3:28 PM, portefeuille (99.67) wrote:

bought 1300 CHTP 4.11 USD.

currently 11150 CHTP shares in the fund with break-even of around 3.10 USD.

Report this comment
#63) On February 23, 2011 at 3:35 PM, portefeuille (99.67) wrote:

sell 30 PBR, limit 40 USD.

Report this comment
#64) On February 23, 2011 at 3:38 PM, portefeuille (99.67) wrote:

sold 30 PBR 40.24 USD.

currently 30 PBR shares in the fund with break-even of around 21.85 USD.

Report this comment
#65) On February 23, 2011 at 11:21 PM, HedgeFund007 (90.95) wrote:

you are in pharma-mode Port! Maybe change the name to UltraPharma or UltraBio! hehe

Report this comment
#66) On February 24, 2011 at 3:41 AM, portefeuille (99.67) wrote:

buy 600 PAH3:GY, limit 48.80 EUR.

Report this comment
#67) On February 24, 2011 at 3:50 AM, portefeuille (99.67) wrote:

buy 450 PAH3:GY, limit 55.60 EUR.

Report this comment
#68) On February 24, 2011 at 3:56 AM, portefeuille (99.67) wrote:

buy 450 PAH3:GY, limit 55.60 EUR.

change that to

buy 400 PAH3:GY, limit 56 EUR.

Report this comment
#69) On February 24, 2011 at 4:08 AM, portefeuille (99.67) wrote:

bought 400 PAH3:GY 76.71 USD (55.75 EUR * 1.376 USD/EUR).

currently 1600 PAH3:GY shares in the fund with break-even of around 16.21 EUR.

Report this comment
#70) On February 24, 2011 at 11:22 AM, portefeuille (99.67) wrote:

sell 2500 ATPG, limit 18.60 USD.

Report this comment
#71) On February 24, 2011 at 11:25 AM, portefeuille (99.67) wrote:

sold 2500 ATPG 18.685 USD.

currently 17600 ATPG shares in the fund with break-even of around 5.37 USD.

 

buy 6000 DSCO, limit 1.97 USD.

 

Report this comment
#72) On February 24, 2011 at 11:38 AM, portefeuille (99.67) wrote:

bought 6000 DSCO 1.97 USD.

currently 1286000 DSCO shares in the fund with break-even of around 2.76 USD.

 

sell short (to open) 400 VMW, limit 84.45 USD.

Report this comment
#73) On February 24, 2011 at 11:44 AM, portefeuille (99.67) wrote:

sold short (to open) 400 VMW 84.55 USD.

sell 3400 ZIOP, limit 5.86 USD.

Report this comment
#74) On February 24, 2011 at 11:51 AM, portefeuille (99.67) wrote:

sold 3400 ZIOP 5.88 USD.

sell 2500 ALNY, limit 11.06 USD.

Report this comment
#75) On February 24, 2011 at 11:53 AM, portefeuille (99.67) wrote:

sold 2500 ALNY 11.09 USD.

sell 600 IBB, limit 92.25 USD.

Report this comment
#76) On February 24, 2011 at 11:54 AM, portefeuille (99.67) wrote:

sold 600 IBB 92.27 USD.

buy 34000 DSCO, limit 1.97 USD.

Report this comment
#77) On February 24, 2011 at 12:16 PM, portefeuille (99.67) wrote:

bought 34000 DSCO 1.97 USD.

currently 1320000 DSCO shares in the fund with break-even of around 2.74 USD.

Report this comment
#78) On February 24, 2011 at 12:34 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 24, 2011) with/without DSCO: 29.8/60.2%.

Report this comment
#79) On February 24, 2011 at 1:23 PM, portefeuille (99.67) wrote:

sell 50 PANL, limit 39 USD.

Report this comment
#80) On February 24, 2011 at 1:25 PM, portefeuille (99.67) wrote:

sold 50 PANL 39.30 USD.

sell 50 RVBD, limit 40.30 USD.

Report this comment
#81) On February 24, 2011 at 1:27 PM, portefeuille (99.67) wrote:

sold 50 RVBD 40.46 USD.

sell 60 SGY, limit 28 USD.

Report this comment
#82) On February 24, 2011 at 1:28 PM, portefeuille (99.67) wrote:

sold 60 SGY 28.18 USD.

sell 80 REP, limit 32.90 USD.

Report this comment
#83) On February 24, 2011 at 1:28 PM, portefeuille (99.67) wrote:

sold 80 REP 32.96 USD.

Report this comment
#84) On February 24, 2011 at 1:30 PM, portefeuille (99.67) wrote:

buy 60 ACOR, limit 20.80 USD.

Report this comment
#85) On February 24, 2011 at 1:30 PM, portefeuille (99.67) wrote:

bought 60 ACOR 20.80 USD.

Report this comment
#86) On February 24, 2011 at 5:10 PM, portefeuille (99.67) wrote:

buy 700 TSRX, limit 5.80 USD.

Report this comment
#87) On February 24, 2011 at 5:59 PM, MyunderratedLife (90.83) wrote:

Sorry to be bugging you all the time but I was wondering if the new proposal regarding biologic drug patents being decreased from 12 to 7 years impacts you fundamental outlook on some of your biotech picks?   Or is this just noise?

Report this comment
#88) On February 24, 2011 at 6:11 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 25, 2011) with/without DSCO: 32.15/61%.

Report this comment
#89) On February 24, 2011 at 6:36 PM, portefeuille (99.67) wrote:

#87 It would not be all that great news for some biotech companies.

Report this comment
#90) On February 24, 2011 at 8:41 PM, portefeuille (99.67) wrote:

buy 800 NKTR, limit 10 USD.

Report this comment
#91) On February 24, 2011 at 9:59 PM, portefeuille (99.67) wrote:

The Next Big Move For The Smartest Biotech Investor

currently 19850 ZIOP shares in the fund with break-even of around 5.17 USD.

Report this comment
#92) On February 25, 2011 at 9:38 AM, portefeuille (99.67) wrote:

sell 300 TTHI, limit 4.45 USD.

Report this comment
#93) On February 25, 2011 at 9:39 AM, portefeuille (99.67) wrote:

sold 300 TTHI 4.53 USD.

Report this comment
#94) On February 25, 2011 at 9:42 AM, portefeuille (99.67) wrote:

sell 1300 SVNT, limit 9.73 USD.

Report this comment
#95) On February 25, 2011 at 9:43 AM, portefeuille (99.67) wrote:

sold 1300 SVNT 9.76 USD.

sell 400 STEC, limit 20.57 USD.

Report this comment
#96) On February 25, 2011 at 9:47 AM, portefeuille (99.67) wrote:

sold 400 STEC 20.60 USD.

sell 40 CBOE, limit 28.60 USD.

Report this comment
#97) On February 25, 2011 at 9:48 AM, portefeuille (99.67) wrote:

sold 40 CBOE 28.74 USD.

sell 250 CIE, limit 15 USD.

Report this comment
#98) On February 25, 2011 at 10:37 AM, portefeuille (99.67) wrote:

sold 250 CIE 15.11 USD.

sell 800 ATPG, limit 19.15 USD.

Report this comment
#99) On February 25, 2011 at 10:39 AM, portefeuille (99.67) wrote:

sold 800 ATPG 19.20 USD.

sell 70 VPHM, limit 17.10 USD.

Report this comment
#100) On February 25, 2011 at 10:46 AM, portefeuille (99.67) wrote:

sold 70 VPHM 17.13 USD.

sell 30000 DSCO, limit 2.03 USD,
sell 150 SD, limit 10.10 USD.

Report this comment
#101) On February 25, 2011 at 11:05 AM, portefeuille (99.67) wrote:

sold 150 SD 10.21 USD.

sell 110 ADBE, limit 34.70 USD.

Report this comment
#102) On February 25, 2011 at 11:09 AM, portefeuille (99.67) wrote:

bought 700 TSRX 5.58 USD,
bought 800 NKTR 9.66 USD,
sold 110 ADBE 34.74 USD.

sell 200 TSRX, limit 6 USD.

Report this comment
#103) On February 25, 2011 at 11:20 AM, portefeuille (99.67) wrote:

sold 200 TSRX 6.03 USD.

Report this comment
#104) On February 25, 2011 at 12:02 PM, portefeuille (99.67) wrote:

sold 30000 DSCO 2.055 USD.

sell 20000 DSCO, limit 2.09 USD.

Report this comment
#105) On February 25, 2011 at 12:36 PM, portefeuille (99.67) wrote:

sell 1700 ZIOP, limit 6.20 USD.

Report this comment
#106) On February 25, 2011 at 12:37 PM, portefeuille (99.67) wrote:

sold 1700 ZIOP 6.20 USD.

Report this comment
#107) On February 25, 2011 at 6:29 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 26, 2011) with/without DSCO: 38.45/64.59%.

Report this comment
#108) On February 25, 2011 at 7:24 PM, portefeuille (99.67) wrote:

the largest positions (number of shares, ticker, name, current value, current share price, break-even).
1290000, DSCO, Discovery Laboratories, 2670300.00 USD, 2.07 USD, 2.76 USD,

38550, ALNY, Alnylam Pharmaceuticals, 437928.00 USD, 11.36 USD, 10.22 USD,
15700, EMC, 422330.00 USD, 26.90 USD, 12.85 USD,
16800, ATPG, ATP Oil & Gas, 333984.00 USD, 19.88 USD, 4.71 USD,
22460, SVNT, Savient Pharmaceuticals, 221231.00 USD, 9.85 USD, 8.84 USD,
13810, MNTA, Momenta Pharmaceuticals, 190716.10 USD, 13.81 USD, 15.10 USD,
3850, FXI, iShares FTSE/Xinhua China 25 Index Fund, 161084.00 USD, 41.84 USD, 43.67 USD,

29300, EXAS, Exact Sciences, 158806.00 USD, 5.42 USD, 5.46 USD.

Report this comment
#109) On February 25, 2011 at 7:37 PM, portefeuille (99.67) wrote:

http://quicktake.morningstar.com/etfnet/Holdings.aspx?Country=&Symbol=FXI

Report this comment
#110) On February 25, 2011 at 7:45 PM, portefeuille (99.67) wrote:

#91

-------------

Barclays "Inititate ZIOP with an Overweight & $9 target (potential 57% upside).Attractively valued-sarcoma upside with downside support from recent Intrexon (RJ Kirk) collaboration (rapid throughput understimated)"

Price Target USD 9.00
Price (22-Feb-2011) USD 5.75
Potential Upside/Downside +57%

Attractively Valued - Palifosfamide Key Driver

We are initiating coverage of ZIOP with a 1-Overweight rating and $9/share price target. We believe that upside potential to our price target can be achieved on continued progress with phase 3 development of lead product Zymafos (palifosfamide) in sarcoma with option value to successful trial execution, broadening development to SCLC and pipeline opportunities with Zinapar and Zybulin. We believe that the recent Intrexon collaboration provides downside support and would suggest that upside potential in sarcoma has been over-discounted in the context of positive randomized phase 2 data.

ZIOP is a development stage oncology company focused on inlicensing efforts in areas of significant unmet need. ZIOPs lead opportunity, Zymafos (palifosfamide), is the active metabolite of approved chemotherapeutic ifosfamide and has demonstrated statistically significant improvement in progression free survival (PFS) in a randomized phase 2 trial for patients with advanced soft tissue sarcoma. With a PFS risk reduction of 57% in phase 2 (HR=0.43, p=0.019), ZIOP is currently seeking to confirm benefit with the phase 3 PICASSO study powered for a 40% reduction.

At current valuation levels, we estimate an implied probability of success on a potential $300M global opportunity at 35%, which we believe is too low and expect share price appreciation on execution of enrollment completion. Further option value may exist from development of Zinapar in peripheral T-cell lymphoma (PTCL), Zybulin in solid tumors, and we believe that Intrexon's UltraVector platform provides significant downside support to mitigate risk to any one product event.

INVESTMENT THESIS
Ziopharm Oncology inc. (ZIOP) is a development stage biopharmaceutical company focused on inlicensing and development of novel therapeutics for the treatment of cancer.
 
Relative to other development stage oncology companies we believe that ZIOP offers greater downside protection from its INTREXON platform, is better diversified, with multiple product opportunities, and is more mature in terms of lead product opportunity with Palifosfamide in phase 3 development for soft tissue sarcoma (STS).
 
We believe that ZIOP is attractively valued relative to other phase 3 oncology peers like ARIA and relative to its initial opportunity in soft tissue sarcoma. With peak sales estimate of roughly $300M globally, we estimate an NPV of $9/share. At current levels, we estimate that the Street is pricing in a 35% likelihood of success for Zymafos (palifosfamide) in soft tissue sarcoma, which we believe is too low given 57% PFS benefit seen with prior randomized phase 2 data.
 
Upside potential beyond Zymafos (palifosfamide) success in STS could come from expansion to small cell lung cancer (SCLC) as well as pipeline progress with either Zinapar (darinaparsin) or Zybulin (indibulin). Visibility on INTREXON pipeline opportunities may be limited at present given early stage nature of efforts, however initial focus on IL-12 in melanoma appears promising, and we believe that rapid throughput with INTREXON platform has been under-estimated.

Overall we see limited downside risk for ZIOP over the next 12 months and with phase 3 data for Zymafos (palifosfamide) expected in 2012, we expect ZIOP shares to increasingly outperform as the year progresses. As such, we would be buyers at current levels.

-------------

 

currently 18150 ZIOP shares in the fund with break-even of around 5.08 USD.

 

Report this comment
#111) On February 25, 2011 at 11:51 PM, portefeuille (99.67) wrote:

RNAi Therapeutics is Dead, Long Live RNAi Therapeutics

Clinical Trial Update for Solid Cancer Candidate Atu-027 Highly Encouraging

Silence Therapeutics to Present Blitz-Update on Atu-027

Silence Pres BIO CEO.pdf

 

currently 70000 SLN:LN shares in the fund with break-even of around 2.69 p.

Report this comment
#112) On February 26, 2011 at 3:43 PM, portefeuille (99.67) wrote:

SAC Capital’s Cohen Opens Up

Report this comment
#113) On February 26, 2011 at 9:02 PM, portefeuille (99.67) wrote:

Territory size shows the proportion of all scientific papers published in 2001 written by authors living there.



enlarge

Territory size shows the proportion of worldwide wealth, that is Gross Domestic Product (2002) based on exchange rates with the US$, that is found there.



enlarge

Report this comment
#114) On February 26, 2011 at 10:00 PM, portefeuille (99.67) wrote:

Top 200 Pharmaceutical Products by Worldwide Sales in 2009

Report this comment
#115) On February 28, 2011 at 3:26 AM, portefeuille (99.67) wrote:

sell 2000 BVB:GY, limit 3.34 EUR.

Report this comment
#116) On February 28, 2011 at 3:35 AM, portefeuille (99.67) wrote:

Epigenomics and QIAGEN Sign Collaboration Agreement in Colorectal Cancer Blood Testing

 

currently 17200/6700 ECX:GY/QGEN shares in the fund with break-even of around 2.34 EUR / 18.09 USD.

Report this comment
#117) On February 28, 2011 at 1:39 PM, portefeuille (99.67) wrote:

sold 20000 DSCO 2.09 USD.

sell 300 TTHI, limit 5.12 USD.

Report this comment
#118) On February 28, 2011 at 1:50 PM, portefeuille (99.67) wrote:

sold 300 TTHI 5.13 USD.

sell 650 LGND, limit 10.70 USD,
sell 400 SNTA, limit 5.85 USD.

Report this comment
#119) On February 28, 2011 at 1:52 PM, portefeuille (99.67) wrote:

sold 650 LGND 10.71 USD.

buy 400 EMC, limit 27.10 USD.

Report this comment
#120) On February 28, 2011 at 1:54 PM, portefeuille (99.67) wrote:

bought 400 EMC 27.07 USD.

sell 170 PDLI, limit 5.55 USD.

Report this comment
#121) On February 28, 2011 at 1:57 PM, portefeuille (99.67) wrote:

sold 170 PDLI 5.59 USD.

Report this comment
#122) On February 28, 2011 at 2:36 PM, portefeuille (99.67) wrote:

buy to cover 300 VMW, limit 83.80 USD.

Report this comment
#123) On February 28, 2011 at 2:37 PM, portefeuille (99.67) wrote:

bought to cover 300 VMW 83.72 USD.

Report this comment
#124) On February 28, 2011 at 2:55 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - February 28, 2011) with/without DSCO: 37.19/64.06%.

Report this comment
#125) On February 28, 2011 at 3:21 PM, portefeuille (99.67) wrote:

buy 200 NPSP, limit 7.70 USD.

Report this comment
#126) On February 28, 2011 at 3:22 PM, portefeuille (99.67) wrote:

bought 200 NPSP 7.62 USD.

Report this comment
#127) On February 28, 2011 at 3:53 PM, portefeuille (99.67) wrote:

sell 120 TRGT, limit 28.60 USD.

Report this comment
#128) On February 28, 2011 at 3:59 PM, portefeuille (99.67) wrote:

sold 120 TRGT 28.67 USD.

sell 400 CBRX, limit 3.40 USD.

Report this comment
#129) On February 28, 2011 at 3:59 PM, portefeuille (99.67) wrote:

sold 400 CBRX 3.49 USD.

Report this comment
#130) On February 28, 2011 at 4:28 PM, portefeuille (99.67) wrote:

sell 1200 NVAX, limit 3 USD in extended or regular trading.

Report this comment
#131) On February 28, 2011 at 4:30 PM, portefeuille (99.67) wrote:

HHS Awards Contracts to Develop New Flu Vaccine Technology Two contracts support advanced development of next-generation recombinant vaccine

Report this comment
#132) On February 28, 2011 at 5:01 PM, portefeuille (99.67) wrote:

sell 700 TSRX, limit 6.60 USD.

Report this comment
#133) On March 01, 2011 at 5:58 AM, portefeuille (99.67) wrote:

sell 200 EPI, limit 23.25 USD.

Report this comment
#134) On March 01, 2011 at 12:02 PM, portefeuille12 (39.69) wrote:

sold 700 TSRX 6.75 USD,
sold 1200 NVAX 3.50 USD,
sold 200 EPI 23.31 USD.

Report this comment
#135) On March 01, 2011 at 12:07 PM, portefeuille (99.67) wrote:

buy 4000 ATPG, limit 20.25 USD.

Report this comment
#136) On March 01, 2011 at 12:10 PM, portefeuille (99.67) wrote:

bought 4000 ATPG 20.25 USD.

currently 20800 ATPG shares in the fund with break-even of around 7.70 USD.

Report this comment
#137) On March 01, 2011 at 12:12 PM, portefeuille (99.67) wrote:

buy 40000 DSCO, limit 2.02 USD.

Report this comment
#138) On March 01, 2011 at 12:25 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - March 1, 2011) with/without DSCO: 36.45/63.69%.

Report this comment
#139) On March 01, 2011 at 1:04 PM, portefeuille (99.67) wrote:

sell 2500 ATPG, limit 20.79 USD.

Report this comment
#140) On March 01, 2011 at 1:20 PM, portefeuille (99.67) wrote:

sell 30 BIIB, limit 70.40 USD.

Report this comment
#141) On March 01, 2011 at 1:27 PM, portefeuille (99.67) wrote:

sold 30 BIIB 70.52 USD.

sell 1400 VICL, limit 2.20 USD.

Report this comment
#142) On March 01, 2011 at 1:31 PM, portefeuille (99.67) wrote:

sold 1400 VICL 2.21 USD.

Report this comment
#143) On March 01, 2011 at 1:33 PM, portefeuille (99.67) wrote:

bought 40000 DSCO 2.02 USD.

currently 1310000 DSCO shares in the fund with break-even of around 2.75 USD.

Report this comment
#144) On March 01, 2011 at 2:26 PM, portefeuille9 (95.48) wrote:

buy 70 ECH, limit 68.60 USD.

Report this comment
#145) On March 01, 2011 at 2:29 PM, portefeuille9 (95.48) wrote:

bought 70 ECH 68.58 USD.

currently 325 ECH "shares" in the fund with break-even of around 56.14 USD.

Report this comment
#146) On March 01, 2011 at 3:10 PM, portefeuille (99.67) wrote:

sell 800 TSRX, limit 7.15 USD.

Report this comment
#147) On March 01, 2011 at 4:08 PM, Nickalisk (53.38) wrote:

Re: #108 

Any chance you would post your top 10 "real" portfolio holdings to compare?

Report this comment
#148) On March 01, 2011 at 4:13 PM, portefeuille (99.67) wrote:

sold 800 TSRX 7.20 USD.

Report this comment
#149) On March 01, 2011 at 4:19 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - March 1, 2011) with/without DSCO: 36.33/62.78%.

#147 No, I quit posting my portfolio positions.

Report this comment
#150) On March 01, 2011 at 5:13 PM, portefeuille (99.67) wrote:

German Luxury-Car Makers Report Monthly Sales Surge on China, U.S. Demand

Report this comment
#151) On March 01, 2011 at 5:26 PM, portefeuille (99.67) wrote:

Germany's Unemployment Shrinks Three Times as Fast as Economists Estimated

 

unemployment rate (from here (pdf)).



enlarge

Report this comment
#152) On March 02, 2011 at 1:18 AM, portefeuille (99.67) wrote:

sell 3500 CFW, limit 0.62 USD in extended or regular trading.

currently 7000 CFW shares in the fund with break-even of around 0.19 USD.

Report this comment
#153) On March 02, 2011 at 9:30 AM, portefeuille (99.67) wrote:

sell 3500 CFW, limit 0.62 USD in extended or regular trading.

change that to

sell 3500 CFW, limit 0.55 USD.

Report this comment
#154) On March 02, 2011 at 9:44 AM, portefeuille (99.67) wrote:

sold 3500 CFW 0.57 USD.

sell 220 SGL:GY, limit 31.40 EUR.

Report this comment
#155) On March 02, 2011 at 10:03 AM, portefeuille (99.67) wrote:

sell 120 RPRX, limit 6.30 USD.

Report this comment
#156) On March 02, 2011 at 10:04 AM, portefeuille (99.67) wrote:

sold 120 RPRX 6.44 USD.

sell 70 YHOO, limit 17.20 USD.

Report this comment
#157) On March 02, 2011 at 10:13 AM, portefeuille (99.67) wrote:

buy 30 SINA, limit 75 USD.

Report this comment
#158) On March 02, 2011 at 10:13 AM, portefeuille (99.67) wrote:

bought 30 SINA 74.73 USD.

Report this comment
#159) On March 02, 2011 at 12:02 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - March 2, 2011) with/without DSCO: 38.63/64.31%.

Report this comment
#160) On March 02, 2011 at 1:34 PM, portefeuille (99.67) wrote:

sell 3000 SVNT, limit 10.11 USD.

Report this comment
#161) On March 02, 2011 at 1:36 PM, portefeuille (99.67) wrote:

sold 3000 SVNT 10.12 USD.

currently 19460 SVNT shares in the fund with break-even of around 8.65 USD.

Report this comment
#162) On March 02, 2011 at 1:42 PM, portefeuille (99.67) wrote:

sell 400 CLDX, limit 4.10 USD.

Report this comment
#163) On March 02, 2011 at 1:46 PM, portefeuille (99.67) wrote:

sold 400 CLDX 4.12 USD.

currently 800 CLDX shares in the fund with break-even of around 4.59 USD.

 

buy 500 TSRX, limit 6.50 USD.

Report this comment
#164) On March 02, 2011 at 1:47 PM, portefeuille (99.67) wrote:

bought 500 TSRX 6.45 USD.

currently 2000 TSRX shares in the fund with break-even of around -4.17 USD.

Report this comment
#165) On March 02, 2011 at 3:13 PM, portefeuille (99.67) wrote:

buy 1500 NKTR, limit 9.15 USD.

Report this comment
#166) On March 02, 2011 at 3:15 PM, portefeuille (99.67) wrote:

bought 1500 NKTR 9.15 USD.

currently 3830 NKTR shares in the fund with break-even of around 10.78 USD.

Report this comment
#167) On March 03, 2011 at 12:09 PM, portefeuille (99.67) wrote:

buy 1500 NKTR, limit 8.70 USD.

Report this comment
#168) On March 03, 2011 at 12:14 PM, portefeuille (99.67) wrote:

bought 1500 NKTR 8.61 USD.

currently 5330 NKTR shares in the fund with break-even of around 10.17 USD.

 

buy 2500 NKTR, limit 8.35 USD.

Report this comment
#169) On March 03, 2011 at 12:34 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - March 2, 2011) with/without DSCO: 38.81/65.26%.

 

sell 220 ITMN, limit 39.65 USD.

Report this comment
#170) On March 03, 2011 at 12:37 PM, portefeuille (99.67) wrote:

sold 220 ITMN 39.70 USD.

currently 1000 ITMN shares in the fund with break-even of around -95.61 USD.

Report this comment
#171) On March 03, 2011 at 12:46 PM, portefeuille (99.67) wrote:

sold 220 SGL:GY 43.55 USD (31.40 EUR * 1.3868 USD/EUR).

Report this comment
#172) On March 03, 2011 at 1:49 PM, portefeuille (99.67) wrote:

sell 90 SGI, limit 18 USD.

Report this comment
#173) On March 03, 2011 at 1:51 PM, portefeuille (99.67) wrote:

sold 90 SGI 18.21 USD.

currently 70 SGI shares in the fund with break-even of around -38.90 USD.

Report this comment
#174) On March 03, 2011 at 2:41 PM, portefeuille (99.67) wrote:

sell 700 RIGL, limit 7.22 USD.

Report this comment
#175) On March 03, 2011 at 2:42 PM, portefeuille (99.67) wrote:

sold 700 RIGL 7.24 USD.

currently 4850 RIGL shares in the fund with break-even of around 8.24 USD.

Report this comment
#176) On March 03, 2011 at 4:37 PM, portefeuille (99.67) wrote:

buy 600 PAH3:GY, limit 48.80 EUR
sell 2000 BVB:GY, limit 3.34 EUR
sell 400 SNTA, limit 5.85 USD
sell 2500 ATPG, limit 20.79 USD
sell 70 YHOO, limit 17.20 USD
buy 2500 NKTR, limit 8.35 USD

cancel these orders.

 

rel. change of fund (March 8, 2010 - March 3, 2011) with/without DSCO: 39.98/66.05%.

Report this comment
#177) On March 03, 2011 at 8:46 PM, portefeuille (99.67) wrote:

sell 490 RSX, limit 41 USD.

Report this comment
#178) On March 03, 2011 at 11:33 PM, portefeuille (99.67) wrote:

Hedge Fund Titan's Principles

Report this comment
#179) On March 04, 2011 at 3:20 AM, portefeuille (99.67) wrote:

sell 100 EWO, limit 22.70 USD,
sell 1200 IRWD, limit 12.20 USD,
sell 1700 QGEN, limit 20.60 USD.

Report this comment
#180) On March 04, 2011 at 6:38 AM, portefeuille (99.67) wrote:

buy 150 SPY $110 June 2011 put options (SPY110618P00110000), limit 0.73 USD.

Report this comment
#181) On March 04, 2011 at 9:52 AM, portefeuille (99.67) wrote:

buy 300 VVUS, limit 6.80 USD.

Report this comment
#182) On March 04, 2011 at 10:28 AM, portefeuille (99.67) wrote:

bought 300 VVUS 6.67 USD.

buy 600 TSRX, limit 5.75 USD.

Report this comment
#183) On March 04, 2011 at 10:32 AM, portefeuille (99.67) wrote:

sold 490 RSX 41.39 USD,
sold 100 EWO 22.74 USD,
sold 1200 IRWD 12.53 USD,
sold 1700 QGEN 20.68 USD,
bought 600 TSRX 5.73 USD.

sell 450 ITMN, limit 42.30 USD.

Report this comment
#184) On March 04, 2011 at 10:35 AM, portefeuille (99.67) wrote:

sold 450 ITMN 42.30 USD.

sell 1300 EXAS, limit 5.45 USD.

Report this comment
#185) On March 04, 2011 at 10:54 AM, portefeuille (99.67) wrote:

sold 1300 EXAS 5.50 USD.

rel. change of fund (March 8, 2010 - March 4, 2011) with/without DSCO: 37.69/65.3%.

Report this comment
#186) On March 04, 2011 at 10:56 AM, portefeuille (99.67) wrote:

buy 900 PBTH, limit 5.20 USD.

Report this comment
#187) On March 04, 2011 at 10:58 AM, portefeuille (99.67) wrote:

bought 900 PBTH 5.15 USD.

currently 17650 PBTH shares in the fund with break-even of around 4.24 USD.

Report this comment
#188) On March 04, 2011 at 11:31 AM, portefeuille (99.67) wrote:

buy 120000 DSCO, limit 2.01 USD.

Report this comment
#189) On March 04, 2011 at 12:07 PM, portefeuille (99.67) wrote:

Sustainable development in Germany

Report this comment
#190) On March 04, 2011 at 2:50 PM, portefeuille (99.67) wrote:

sell 250 ACHN, limit 5.90 USD.

Report this comment
#191) On March 04, 2011 at 2:52 PM, portefeuille (99.67) wrote:

sold 250 ACHN 5.98 USD.

currently 350 ACHN shares in the fund with break-even of around -3.05 USD.

Report this comment
#192) On March 04, 2011 at 3:57 PM, portefeuille (99.67) wrote:

sell 80 GHDX, limit 25.40 USD.

Report this comment
#193) On March 04, 2011 at 3:58 PM, portefeuille (99.67) wrote:

sold 80 GHDX 25.57 USD.

sell 80 GILD, limit 40.60 USD.

Report this comment
#194) On March 04, 2011 at 3:59 PM, portefeuille (99.67) wrote:

sold 80 GILD 40.74 USD.

sell 300 HERO, limit 5.90 USD.

Report this comment
#195) On March 04, 2011 at 4:01 PM, portefeuille (99.67) wrote:

sold 300 HERO 5.91 USD.

 

buy 120000 DSCO, limit 2.01 USD.

cancel that order.

Report this comment
#196) On March 04, 2011 at 4:30 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - March 4, 2011) with/without DSCO: 36.78/65.16%.

Report this comment
#197) On March 05, 2011 at 12:15 PM, portefeuille (99.67) wrote:

sell 410 PXQ, limit 28.80 USD.

Report this comment
#198) On March 05, 2011 at 12:28 PM, portefeuille (99.67) wrote:

buy 2000 QTM, limit 2.70 USD.

Report this comment
#199) On March 07, 2011 at 6:20 AM, portefeuille (99.67) wrote:

Top hedge funds betting on plastics

 

currently 140/110 LYB/REP:SM shares in the fund with break-even of around12.80 USD / 9.88 EUR.

Report this comment
#200) On March 07, 2011 at 6:44 AM, portefeuille (99.67) wrote:

Tired of Storm Risks, ATP Oil and Gas Expands Into Offshore Israel 

Is Offshore Israel Expansion a Good Thing for ATP Oil and Gas?

 

currently 20800 ATPG shares in the fund with break-even of around 7.70 USD.

Report this comment
#201) On March 07, 2011 at 9:47 AM, portefeuille (99.67) wrote:

sold 410 PXQ 28.90 USD,
bought 2000 QTM 2.69 USD.

Report this comment
#202) On March 07, 2011 at 9:58 AM, portefeuille (99.67) wrote:

sell 2000 CFW, limit 0.74 USD.

Report this comment
#203) On March 07, 2011 at 9:59 AM, portefeuille (99.67) wrote:

sold 2000 CFW 0.742 USD.

Report this comment
#204) On March 07, 2011 at 7:16 PM, portefeuille (99.67) wrote:

buy 1000 BCRX, limit 4.30 USD.

Report this comment
#205) On March 07, 2011 at 9:46 PM, portefeuille (99.67) wrote:

buy 1400 ALTH, limit 3 USD.

Report this comment
#206) On March 07, 2011 at 9:52 PM, portefeuille (99.67) wrote:

rel. change of fund (March 8, 2010 - March 8, 2011) with/without DSCO: 34.05/62.81%.

Report this comment
#207) On March 07, 2011 at 10:29 PM, portefeuille (99.67) wrote:

continued here.

Report this comment

Featured Broker Partners


Advertisement