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A pharmaceutical company which is engaged in the development of drugs for the treatment of severe psychiatric and metabolic diseases.
Corcept continues to flog Corlux, its pipeline in a teacup. The stock continues to get diluted as the phase III study of Corlux in Cushing's syndrome approaches a topline data release in mid-2010. As there is minimal clinical data for efficacy in Cushing's to support the phase III study, I'm not going to get my buffalo hump in a lather over it. The phase III study in psychotic depression is a joke, with obvious enrollment issues in the wake of multiple prior failures for the same indication.
I wouldn't count mifepristone out wrt treating Cushing's syndrome, or at least acute cortisol-induced psychosis. Especially in non-iatrogenic cases, when it me be difficult to treat the primary cause of Cushing's, perhaps if it's caused by an andrenal neoplasm, mifepristone may be the best option.
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