Vertex Pharmaceuticals, Inc. (NASDAQ:VRTX)

CAPS Rating: 3 out of 5

The Company is in the business of discovering, developing and commercializing small molecule drugs for the treatment of serious diseases.

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Member Avatar TSIF (99.96) Submitted: 7/3/2014 8:07:38 PM : Underperform Start Price: $97.67 VRTX Score: +0.25

Very erratic, $22B market cap??

18X book, burn $300M year. 40% share price bump for cystic fibrosis. 4% with specific mutation. $7B to market cap might be warranted eventually, but not all at once.

Short term contrarian call....probably not worth the trouble.

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Member Avatar MichaelHamilton (99.13) Submitted: 6/24/2014 10:12:22 PM : Underperform Start Price: $92.26 VRTX Score: -4.11

$22bn,really??

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Member Avatar naughtyguy (30.59) Submitted: 6/24/2014 11:57:13 AM : Underperform Start Price: $93.18 VRTX Score: -4.15

$22 billion market cap!

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Member Avatar BuffettJunior1 (97.49) Submitted: 6/24/2014 11:54:45 AM : Outperform Start Price: $93.61 VRTX Score: +3.68

Too easy!

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Member Avatar CSLSRX44 (< 20) Submitted: 4/16/2014 7:36:21 AM : Outperform Start Price: $63.81 VRTX Score: +46.70

Has been beaten down

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Member Avatar Stan1955 (51.77) Submitted: 4/11/2014 5:24:22 PM : Outperform Start Price: $62.89 VRTX Score: +47.15

Have a block buster drug in the wings that will make 3 billion

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Member Avatar d3ming (32.31) Submitted: 1/31/2014 1:31:33 PM : Outperform Start Price: $79.66 VRTX Score: +11.85

zzporte

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Member Avatar Turtlebale (< 20) Submitted: 12/31/2013 2:26:09 PM : Outperform Start Price: $74.03 VRTX Score: +24.68

new CF product should be approved in 2014

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Member Avatar lmct1936 (< 20) Submitted: 12/21/2013 12:36:57 PM : Outperform Start Price: $72.40 VRTX Score: +26.65

WELL, I THINK PEOPLE S VERY INTERESTED IN ALL RELATED WITH HEALTH (FOR ME IS THE FIRST), & PARTICULARLY WITH DISCOVERING RESEARCHES THAT STRUGGLE WITH BIG DESEASES SUCH CANCER, DIABETES, ETC.

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Member Avatar bachroxx (58.06) Submitted: 4/25/2013 2:57:30 PM : Underperform Start Price: $80.16 VRTX Score: +2.78

CFO just sold $39M of stock and leap is just based on Jim Cramer's word and phase 2 trials of a new CF drug.

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Member Avatar chris293 (85.07) Submitted: 2/27/2013 10:13:18 PM : Outperform Start Price: $46.89 VRTX Score: +78.53

Vertex is on the leading edge for new cures of many dieases and inflections. Maybe the year of stocks ending with an 'x' is back. Micro-cures could be the answers to what ails us.

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Member Avatar ajcmr3 (93.57) Submitted: 2/8/2013 5:32:32 PM : Outperform Start Price: $46.51 VRTX Score: +79.14

Positioned to become the leading Cystic Fibrosis franchise. 2013 a transition year as HCV franchise rolls off.

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Member Avatar JorgeAura (25.78) Submitted: 2/2/2013 5:38:13 PM : Underperform Start Price: $44.66 VRTX Score: -87.60

Nasdaq in maximums.

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Member Avatar zzlangerhans (99.70) Submitted: 11/3/2012 2:26:33 AM : Outperform Start Price: $47.47 VRTX Score: +66.07

Trading Vertex now is like the old days, when the valuation rose and fell based on prospects rather than sales. It's pretty clear that Incivek isn't the yellow brick road to sustained profitability that it appeared to be a couple of years ago. Now that Vertex is becoming a spec stock again, it's uncertain how far the share price could retreat. I still like the potential of interferon-free Incivek regimens, the cystic fibrosis franchise, and late stage trials of JAK inhibitor VX-509 in RA and influenza.

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Member Avatar flemmingha (56.13) Submitted: 3/24/2012 6:41:52 AM : Outperform Start Price: $41.36 VRTX Score: +96.05

over 20 period moving average

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Member Avatar XMFWhatsmyoption (< 20) Submitted: 7/30/2011 10:11:09 AM : Outperform Start Price: $52.39 VRTX Score: +35.51

earnings positive in 2012 with a blockbuster drug funding the pipeline http://www.vrtx.com/current-projects/drug-candidates/pipeline.html and excess cash . I own it.

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Member Avatar georacer (< 20) Submitted: 7/20/2011 9:56:23 PM : Underperform Start Price: $50.47 VRTX Score: -45.55

Vertex's blockbuster drug Telaprevir, which is used for the treatment of Hepatitis C has a 1 in 3 chance of causing a scarring rash that is so bad that treatment must be stopped. Another drug that has a similar mechanism of action that has just been released, Boceprevir, is also used for the treatment of Hepatitis C is also effective without the scarring rash. Physicians will chose Boceprevir as they do not want the additional burden of grading patients scars as well as the high likelihood of stopping treatment.

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Member Avatar modestus1 (< 20) Submitted: 5/22/2011 7:26:29 PM : Outperform Start Price: $55.05 VRTX Score: +27.77

blockbuster drug

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Member Avatar chang07 (66.44) Submitted: 4/27/2011 9:34:54 AM : Outperform Start Price: $53.90 VRTX Score: +34.80

Hopefully, the FDA will approve their Hep C drug.

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Member Avatar KattyKay (81.32) Submitted: 3/30/2011 8:00:48 PM : Outperform Start Price: $48.44 VRTX Score: +52.80

Vetrex is developing an oral therapy (VX-770) that increases the function of the defective protein that causes cystic fibrosis (CF), a life threatening disease for children. . People that develop CF have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that diminish lung function.

The primary endpoint, improved lung function, was met in the phase 3 study of VX-770 in the study population of children (ages 6 to 11 years) with the identified G551D mutation in the CFTR gene. Vertex is expected to file in the US and Europe for marketing approval in late 2011.

Additionally, phase 2 clinical trials are ongoing evaluating the combination of VX770 with a second drug in development (VX-809) that targets the F508del mutation and promotes CFTR proteins reaching the cell surface in normal amounts.

The availability of a therapy that improve lung function by normalizing CFTR function and expression will benefit the roughly 100,000 people worldwide currently affected with CF.

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